Meet the Director

Sunny Tam, PhD

Director of the PSM Biotechnology

BS, Boston College; PhD, Boston University Medical School; Postdoctoral Fellow, Harvard University School of Public Health

Email: stam@framingham.edu

Sunny Tam, PhD has 20 years of biotechnology and academic experiences in early stage R&D, preclinical testing, assay and technology development following his training from the Harvard University School of Public Health. He has held numerous scientific and management positions in small molecule discovery and protein therapeutic companies including Mitotix, Inc., Texas Biotechology Corporation and Tanox Inc. Dr. Tam is a pioneer in protein microarray development and application of proteomic tools in drug discovery, biomarker discovery and assay development.  He is well published and has contributed significantly toward a number of issued patents and federally awarded grants.  During his tenure as Program Director at Charles River Laboratories and then University of Massachusetts Medical School, Dr. Tam successfully completed numerous projects for major US biopharmaceutical and government sponsors in new protein technology development, further advancing biomarker discovery and product applications in a number of chronic human diseases.  More recently serving as the VP of R&D at Nuclea Bio, he has built a GLP facility for the development of FDA regulated clinical diagnostic assays with novel biomarkers.  At Clark University as a Research Associate Professor, he has established a state of art Proteomic and Metabolomic laboratory for internal research and student teaching.

Selected Publications

Tang JK, Xu Y, Muhlmann GM, Zare F, Khin Y, Tam SW. Temperature shift effect on the chlorobaculum tepidum chlorosomes. Photosynthesis Research, 115(1): 23-41, 2013.

Low HP, Tiwari A, Janjanam J, Qiu L, Chang CI, Strohsnitter WC, Norwitz ER, Tam SW, Evans JE, Green KM, Paulo JA, Lambe M, Hsieh CC. Screening preeclamptic cord plasma for proteins associated with decreased breast cancer susceptibility. Genomics Proteomics Bioinformatics, 11(6): 335-44, 2013.

Lan WK., Horn MJ., Urano F., Kopoyan A., and Tam SW. Subcellular Fractionation Using Step-Wise Density Extraction for Mass Spectrometry Analysis. Methods in Proteomic Sample Preparation, Springer, Chapter 12, 2011.

Kruger AJ, Yang C, Tam SW, Hinerfeld D, Evans JE, Green KM, Leszyk J, Guberski DL, Mordes JP, Greiner DL, Rossini AA and Bortell R. Haptoglobin is an early serum biomarker of virally induced type 1 diabetes in BBDR rats. Experimental Biology and Medicine, 235(11): 1328-1337, 2010.

Byerley LO, Leamy L, Tam SW, Chou CW, Ravussin E, Development of a serum profile for healthy aging. Journal of Gerontology, 4: 497-507, 2010.

Romero R, Kusanovic JP, Gotsch F, Erez O, Vaisbuch E, Mazaki-Tovi S, Moser A, Tam SW, Leszyk J, Master SR, Juhasz P, Pacora P, Ogge G, Gomez R, Yoon BH, Yeo L, Hassan SS, Rogers WT.Isobaric labeling and tandem mass spectrometry: a novel approach for profiling and quantifying proteins differentially expressed in amniotic fluid in preterm labor with and without intra-amniotic infection/inflammation. Journal of Maternal Fetal Neonatal Medicine. 23(4): 261-280, 2010.

Tam SW. Electrophoretic prefractionation: New commercial tools from an old concept. Expert Review, Proteomics. 3(4): 379-81, 2006.

Davis MA, Hinerfeld D, Joseph S, Hui YH, Huang N, Leszyk J, Rutherford-Bethard J, Tam SW. Proteomic analysis of rat liver phosphoproteins after treatment with protein kinase inhibitor H89. Journal of Pharmacololgy and Experimental Therapeutics. 318(2): 589-595, 2006.

Tam SW, Huang L, Hinerfeld D, Innamorati D, Fang XM, Zhang WW, Pirro J & Feitelson JS. Novel plasma protein separation strategy using multiple avian IgY antibodies for proteomic analysis. Separation Methods In Proteomics, edited by Smejkal and Lazarev., 2005.

Tam SW, Pirro J and Hinerfeld D. Depletion and fractionation technologies in plasma proteomic analysis. Expert Review in Proteomics. 1(4): 1- 10, 2004.

Hinerfeld D, Innamorati D, Pirro J, and Tam SW. Serum/plasma depletion with chicken IgY antibodies for proteomic analysis from multiple mammalian species. Journal of Biomolecular Techniques. 15: 184-190, 2004.

Tam SW, Demissie S, Thomas D and Daeron M. A bispecific antibody against human IgE and human FcgRII that inhibits antigen-induced histamine release by human mast cells and basophils. Allergy 59: 772-780, 2004.

Tam SW, Wiese R, Lee S, Gilmore J and Kumble KD. Simultaneous analysis of human Th1/Th2 cytokines using microarray. Journal of Immunol Methods, 261: 157-165, 2002.

Huang JX, Mehrens D, Wiese R, Lee S, Tam SW, Daniel S, Gilmore J, Shi M, and Lashkari D. High-throughput genomic and proteomic analysis using microarray technology. Clinical Chemistry. 47: 1912-1916, 2001.

Cho C, Tam SW, Demissie S and Oh CK. Plasminogen activator inhibitor for airway remodeling. Journal of Immunology, 165: 3154-3161, 2000.